Classical photo shops also sell hydroquinone. The document was not able to download due to an unknown error. The drug is freely soluble in water and in alcohol. 0.6. glycerin, 2.5. Hydroquinone - an overview | ScienceDirect Topics 0000002379 00000 n It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. Color stability improvement is evident at all levels. All information collection is solely used to support ChemPoint customers service communications. D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. G(DC:!c?5w [QDP, f\01j&8ea]Ke~z d _5H^j0M.|Y^bYb[Rm~-[ImSv. ;4kNNw?r yn^EOwCDyd>_?TU^vyss*|g9A1 avr 2o~molpb|CZTu(70 CKRu)(5O_^6|Qta', uG70]'vt|n3Xh[vMTc.{o0Y#(O5\/mGfI+L0~1E1~hi:ZY_W6n*EaSn*R+I)Pw|y\^/te;yO. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. F. Whler (1844) "Untersuchungen ber das Chinon" (Investigations of quinone). It is not to be considered as either a warranty or quality specification. 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . Other adverse effects Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. Solubility of Hydroquinone in Different Solvents from 276.65 K to 345. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. vz >I d50dwp?i4,H3. Gerhard Franz, Roger A. Sheldon "Oxidation" in. A specific embodiment of the invention is listed in the following table. 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Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. However, a problem with a formulation containing both retinoids and hydroquinone has been their incompatible pH ranges. Eng. 0000002544 00000 n Have an order or account question? The composition is preferably formulated in separate phases as designated below. This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. HYDROQUINONE (hahy droh kwi NOHN) is applied to the the skin to lighten areas that have darkened. Then add it to the ingredients. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. Boucif Belhachemi. These can be burning, redness, sensitization and irritation in some patients. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. 0 7 r @ &. Compositions according to this invention may include additives or components to enhance the skin penetration of its ingredients. INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. How to dissolve Hydroquinone to make 4 oz. Chim. [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. Variations in pH have proven to result in excessive discoloration ranging from brownish to black. N')].uJr Cite this article. 374 0 obj << /Linearized 1 /O 376 /H [ 807 1414 ] /L 581425 /E 96582 /N 109 /T 573826 >> endobj xref 374 19 0000000016 00000 n . [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. The Molecular Weight is 110.11 g/mol. If you are already a ChemPoint customer then sign up for access to our online ordering website. If youre making your lotion. It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims.
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