Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. First Name Tina. S. Shnaider received support from theRussian Science Foundation (no. But she came up with a way to break down the code and create a website that she was proud of. ), Science . Do you agree to our cookie policy? Quat. Fu, Q. et al. This website is about taking one step at a time to ultimately live more fulfilling lives. Considering a freshwater reservoir signal in the upper Volga region making radiocarbon dates on human remains appear up to about 500 years older than their true age44, there could be an interval of more than 1,000 years between the first evidence of admixture in central European hunter-gatherers with Sidelkino ancestry and eastern European hunter-gatherers with Oberkassel ancestry. Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. Google Scholar. 5). Ringbauer, H., Novembre, J. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. Nature 514, 445449 (2014). Here, data really gets to shine, in that its both the source of truth and the driver of insights. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. Bioinformatics 29, 16821684 (2013). By the year 2014 however, 'vape' was named Oxford Dictionary's word of the year. . 29, 11691177.e7 (2019). Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Bioinformatics 20, 289290 (2004). 27, 32023208.e9 (2017). In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. The Neolithic transition in the Baltic was not driven by admixture with early European farmers. Nat. Curr. Extended Data Fig. Data science is a lot like cooking. Genome Res. Her advice appears very solid, and she knows about the difficulties and barriers students are faced often when preparing for job interviews. Product development is, by far, my favorite data science use case for two main reasons. Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". Are you Tina Huang? Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. This often involves analyzing similar products to compare how they performed. 40,000-year-old individual from Asia provides insight into early population structure in Eurasia. TV Actress. After DNA lysis, a subset of samples was extracted using silica-coated magnetic particles on an automated liquid handling system (Agilent Technologies Bravo NGS Workstation)57. Nature thanks Marta Mirazn Lahr, Ludovic Orlando and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Rev. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. Data warehousing is a field where you often have to deal with a lot of raw data. I'm interested in tech, trading, and how to minimize effort and maximize outcome. Questions? Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. "The data we gained from this study provides us with astonishingly detailed insights into the developments and encounters of West Eurasian hunter-gatherer groups," Posth summarises. wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. Wren, C. D. & Burke, A. Habitat suitability and the genetic structure of human populations during the Last Glacial Maximum (LGM) in Western Europe. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Learn with a sense of purpose. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. Tina Huang is a recent graduate of Stanford. My name is Tina and I'm a data scientist and YouTuber. In addition to this general data science content, Tina teaches SQL . In the video above, she explains the two major components of big data: data warehousing and data science. The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. First, I like it because of how powerful (almost magical) it is in driving decisions. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. The length of each coloured bar represents the fraction of individuals carrying the corresponding haplogroup (legend on the right of each panel). This course is the perfect balance of teaching technical SQL concepts and optimal approaches to solving coding questions on interviews. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. Check it out! The IntCal20 Northern Hemisphere radiocarbon age calibration curve (055 cal kbp). Tina Huang Profile page. You also get a peek at Tina's Resume, so I don't think you want to miss out on that. The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Once we have the data, we begin to tease out the high-impact insights. These data suggest that the genetic ancestries identified in the pre-40ka individuals analysed so far went largely extinct or were assimilated by subsequent expansions1,9. "Ice Age survivors." To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. It is not intended to provide medical or other professional advice. Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). This suggests that between the Early/Middle and Late Gravettian there was an east-to-west expansion of the Vstonice-associated ancestry that reached central-western Europe and created a longitudinal admixturecline between those two genetically distinct pre-LGM populations. Petr, M., Pbo, S., Kelso, J. Genetics 203, 881891 (2016). a,b, The ancestries of individuals in the GoyetQ-2 cluster and Iberian hunter-gatherers (HGs) (a) and individuals in the Oberkassel cluster (b) were modelled using qpAdm, with Fournol 85 and Arene Candide 16 representing the Fournol and Villabruna ancestries, respectively. Designed for aspiring data scientists, data analysts, and BI analysts, this course is the perfect resource for anyone who needs a winning strategy to pass the SQL interview and land their dream job. Nucleic Acids Res. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. Details are provided in Data S2.B. Moreover, two of the oldest published groups from western Russia belonging to the Sidelkino clusterPeschanitsa (13ka)43 and the newly reported Minino individuals (11ka)showed extra affinity to the Oberkassel cluster, possibly owing to variability in this ancestry proportion during the initial formation phase of the Sidelkino-ancestry profile. Claim Author Page. L. Sineo, M.L. This button displays the currently selected search type. 14 following. The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. The genetic history of Ice Age Europe. Contact Us. Mittnik, A. et al. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. B. et al. Previous studies identified two different genetic compositions in Magdalenian-associated individualsthe GoyetQ2 cluster including central-western European genomes dated to around 15ka (from France, Belgium and Germany), and the ancestry of the El Mirn individual from Spain4,14 from around 19ka. How to Rock at Data Science with Tina Huang, Older: Daily Habit #8: Math or Computer Science Exercise . & Vernot, B. Kircher, M., Sawyer, S. & Meyer, M. Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. Rivollat, M. et al. I Agree, Brandwatch Bulletin #41: 7 Women in Tech You ShouldKnow. 4a and Supplementary Data 3.C). Sikora, M. et al. Curr. The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. 2a). a, Population structure among Epigravettian-associated populations revealed by a neighbour-joining tree based on pairwise f2 genetic distances. Teaching Assistant. Nature 582, 384388 (2020). Each bar represents one individual with the ROH grouped in four length categories (grouped by colour). 26, 827833 (2016). Nature 592, 253257 (2021). Google Scholar. However, the extent to which groups associated with the Solutrean culture are in genetic continuity with earlier and later populations from the same region is unknown because no genomic data from Solutrean-associated individuals have been reported previously. Open access funding provided by Max Planck Society. 5). My main tasks: Modeling and developing the data structures and processes to optimize the loads of information, discovering insights and creating and maintaining reports. Despite this wide geographical range, it is not clear whether different groups associated with this culture originated from a common source population and how those groups were genetically related to each other. Genomic data have shown that modern humans were present in western Eurasia1,2 at least 45ka. The responsible co-authors for the material from each archaeological site are listed in Supplementary Information, section 1. It just raised $12.2 million. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). Nakatsuka, N. et al. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). Surprisingly, the research team found that populations from different regions associated with the Gravettian culture, which was widespread across the European continent between 32,000 and 24,000 years ago, were not closely related to each other. Subsequently, I worked in . Ancient admixture in human history. H. Rougier, I.C., L.K.,A. Morala, M. Ru, S.M., L.C., J.-B.C., E. Bocaege, S. Ricci, F.B., P. Bayle, B.M., F.L.B.-R., J.-G.B., G.O., E. Bortolini, O.B.-L., G.D., M.O., A.Z., V.S., E.S., L. Sineo, J.v.d.P., L. Pecqueur, G.M., G.G., J.-M.L., C.B.G., A.G.-O., M.P.-B., D.B., M.L.L., P. Storm, C.H., J. Kabaciski, T. Filimonova, S.Shnaider, N.B., B.G.-R., M.R.G.M., A.B.M.-A., B.L., C.A.-L., A.R., C. Polet, I.J., N. Cauwe, J.Soler, N. Coromina, I.R., R.C., G. Clark, L.G.S., M.-A.J., S. Rehart, D.T., S.B., M. Romandini, L.A., H. Bocherens, C.W., S. Villotte, J.F.-L.d.P., M.G.-P., M.A.E.-B., P. Bodu, L. Smits, B.S., R.J., J. Kozakait, C.C., H. Benthien, K.W., R.W.S., S.C.F., T. Schler, C.T., D.G., F.L., A. Kotula, H.P., F.S., J.Svoboda, S.Szelov,A.C., A. Khokhlov, N.J.C., F.V., K.H., P. Semal, B.J., A. Suvorov, R. Schulting, V.M., K.M., A.B. Its like the different ingredients in your recipe. C. Posth and H.Y. Shes also the creator of the Microsoft Excel spreadsheet Data Mining 101. She has also published a book titled Data Science: Principles and Practices which she wrote with co-author Dan Ariely. Yu Ting Wang, Wen Lin Huang, Yan Ting Cheng. Hi! Quat. Don't be shy, get in touch. ScienceDaily. In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. Ideally, we also want lots of data because this will give us more confidence in our results. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Photo by Sara Kurfe on Unsplash 1. Inconsistent haplogroup assignments were manually verified as indicated24 (Supplementary Data 1.L). The lsqproject: YES parameter was used to minimize the effect of missing data in ancient individuals.
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